Study: Weight Loss, Exercise Help Overweight Adults With Knee Osteoarthritis

Combining moderate weight loss and exercise is an effective treatment for overweight adults with osteoarthritis of the knee, according to a study reported in the May issue of the journal Arthritis & Rheumatism.

Arthritis is the leading cause of physical disability in adults, affecting more than 70 million Americans. Marked by joint damage and chronic pain, osteoarthritis is the most common form of arthritis.

Co-researcher Stephen Messier, professor of health and exercise science at Wake Forest University, and his colleagues found that participants in an 18-month program of exercise and calorie-restricted diet had a 24 percent improvement in physical function. Participants in this group also reported the most significant improvements in knee pain – a decrease of more than 30 percent.

Messier said problems with current treatments such as anti-inflammatory drugs with potentially serious long-term side effects and surgery that can be ineffective heighten the need for an alternative therapy. He said the study results give strong support to the combination of exercise and weight loss as a cornerstone for the treatment of overweight osteoarthritis patients.

The study measured improvement in physical function, pain and mobility in 252 randomized participants, all age 60 or older, who were overweight, sedentary and had knee pain or knee osteoarthritis. The participants were divided into one of four groups: exercise only, dietary weight loss only, dietary weight loss plus exercise, and the control group called healthy lifestyle.

The exercise group did aerobic and resistance activities for one hour, three times a week. The diet group attended regular meetings on changing their eating habits and reducing calories in their diets. The combination group, where the most improvement was measured, participated in both programs. The healthy lifestyle group attended classes on weight loss and exercise, but did not participate in the programs.

“We suggest that the combination of diet plus exercise produces consistently better and clinically relevant improvements in physical function compared with diet or exercise alone,” Messier said.

Other sources: Wake Forest University