Analgesics (pain relievers) such as acetaminophen (Tylenol)* and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are used to reduce the pain caused by many rheumatic conditions.

The most commonly used analgesic, acetaminophen, is also the most widely available. Acetaminophen is available under a variety of trade names, including Anacin (aspirin-free), Excedrin, Panadol and Tylenol, without a prescription. It is often the active ingredient in products labeled "aspirin-free" pain reliever.

Because of its cost, effectiveness and safety, the American College of Rheumatology, the professional organization of rheumatologists, recommends acetaminophen as a first-line option against osteoarthritis pain.

Today doctors may prescribe products combining acetaminophen and prescription analgesics such as codeine, hydrocodone or tramadol, as well as other strong analgesics once reserved for severe pain from causes such as injury, cancer or surgery.

Unlike NSAIDs, acetaminophen and other analgesics don't relieve inflammation. Yet studies conducted in recent years suggest acetaminophen relieves arthritis pain - even severe pain - as effectively as NSAIDs.

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